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Untitled Document
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 Medicines for
 Anti Diarrhoeal
Antimicrobial
Antidiabetic
Antacid/Anti peptic ulcerant
Laxative
Ophthalmological
Stomatological
Anitiinflammatory
Herbal
Others
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DETAILS
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| COMPOSITION |
Each tablet contains Gliclazide 40 mg/80 mg. |
| INDICATIONS |
NIDDM |
| MODE OF ACTION |
Being a sulfonylurea hypoglycemic agent it appears to lower blood glucose by stimulating insulin release from beta cells in the pancreatic islet possibly due to increased intracellular cAMP. They may improve the binding between insulin and insulin receptors. Hypoglycemic effects seem to be due to improved beta cell sensitivity or extrapancreatic effects (suppression of glucagon release and hepatic glucose production) occuring in the liver and on insulin sensitivity of peripheral tissues. In vivo studies have demonstrated changes in thrombin-induced platelet aggregation in NIDDM patients treated with gliciazide. Unlike other sulfonylureas or biguanide, gliclazide has been shown to increase significantly the release of plasminogen activator early in the fibrinolytic cascade in sections of rat venae cava. |
| ONSET OF ACTION |
Time to maximum is 4 hours in healthy volunteers. |
| DURATION OF ACTION |
24 hours |
| ADVERSE EFFECT |
Skin rash, urticaria, blood dyscrasias, hypoglycemia. |
| CONTRAINDICATION |
Severe renal and hepatic failure, diabetic precoma and coma, keto-acidosis, pregnancy. |
| SPECIAL PRECAUTIONS |
Periods of metabolic stress, lactation, geriatrics. |
| DRUG INTERACTIONS |
Hypoglycemic effect of glipizide is enhanced by: anti coagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, H2RA, magnesium salt, methyldopa, MAOls, phenylbutazone, probenecid, salicylates, sulfonamides, TCAs and urinary acidifiers. Hypoglycemic effect is inhibited by: beta-blocker, cholestyramine, diazoxide, hydantoins, rifampicin, thiazide diuretics and urinary alkalisers; charcoal reduces the absorption and thus reduces the efficacy or toxicity of glipizide. |
| DOSES |
Adults: usually 180 mg daily in two divided doses; increase if required to 80 to 320 mg daily in two divided doses depending on blood glucose levels. Children: Not recommended. |
| PACKING |
Strip of 10's. |
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Horn 