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DETAILS
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| COMPOSITION |
Each tablet contains: Glipizide 2.5 mg. |
| INDICATIONS |
As an adjunct to diet to lower the blood glucose in patients with non insulin dependent diabetes mellitus whose hyperglycemia cannot be controlled by diet alone. |
| MODE OF ACTION |
Being a sulfonylurea hypoglycemic agent it appears to lower blood glucose by stimulating insulin release from beta cells in the pancreatic islet possibly due to increased intracellularcAMP. They may improve the binding between insulin and insulin receptors. Hypoglycemic effects seem to be dueto improved beta cell sensitivity orextrapancreatic effects (suppression of glucagon release and hepatic glucose production} occuring in the liver and on insulin sensitivity of peripheral tissues. |
| ONSET OF ACTION |
1-1.5 Hours. |
| DURATION OF ACTION |
2 to 4 Hours. |
| ADVERSE EFFECT |
Nausea, vomiting, skin rash, headache, itching, thrombocytopenia, drowsiness, allergic reactions, hypo glycemia. |
| CONTRAINDICATION |
Hepatic and renal failure. Diabetic pre-coma and coma, stress, juvenile diabetes mellitus, pregnancy |
| SPECIAL PRECAUTIONS |
Hypoglycemia, hepatic and renal disease, children, lactat- ing mothers, geriatrics. |
| DRUG INTERACTIONS |
Hypoglycemic effect of glipizide is enhanced by: anti coagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, H2RA, magnesium salt, methylodopa, MAGis, phenylbutazone, probenecid, salicylates, sulfonamides, TCAs and urinary acidifiers. Hypoglycemic effect is inhibited by: beta-blocker, cholestyramine, diazoxide, hydantoins, rifarmpicin, thiazide diuretics and urinary alkalisers; charcoal reduces the absorption and thus reduces the efficacy or toxicity of glipizide. |
| DOSES |
Adults: Initially 2.5 to 5 mg daily 30 min before meals. Increase by 2.5 to 5 mg at weekly intervals to maximum 15 mg daily if required. Children -not recommended |
| PACKING |
Strip of 10's |
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Medicines for
Anti Diarrhoeal
Horn 
