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Untitled Document
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 Medicines for
 Anti Diarrhoeal
Antimicrobial
Antidiabetic
Antacid/Anti peptic ulcerant
Laxative
Ophthalmological
Stomatological
Anitiinflammatory
Herbal
Others
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 Tablets |
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DETAILS
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| COMPOSITION |
Each tablet contains Ofloxacin 200/400 mg . |
| INDICATIONS |
Acute salpingitis ,Bacterial infection prophylaxis, Biliary Tract infection, Bone and Joint infection, Chlamydia Trachomatis infections, Cholera, Chronic Bronchitis, Epididymitis , Gonorrhea, Infectious Diarrhoea, Leprosy, Otorhinolaryngologic infections ,
Pelvic Inflammatory Diseases, Pneumonia, Prostatitis, Pseudomonal infections including Salmonella gastroenteritis, Shigella infections, Skin and Skin Structure Infections, Staphylococcal infections, Tuberculosis , Typhoid fever, Urinary Tract infections. |
| MODE OF ACTION |
Inhibits a bacterial enzyme, DNA gyrase which is required for DNA replication and thus causes bacterial lysis. |
| ONSET OF ACTION |
Within 30 minutes. |
| DURATION OF ACTION |
12-16 hours. |
| ADVERSE EFFECT |
Ofloxacin is generally well-tolerated. During clinical trials in a large number of patients, the most commonly encountered side effects were nausea, epigastric discomfort, vomiting, pseudomembranous colitis, skin rashes, myalgia, arthalgia and bone marrow depression. |
| CONTRAINDICATION |
Patients having a history of epilepsy; Children below 16 years; Pregnant and nursing women; Patient hypersensitive to Ofloxacin. |
| SPECIAL PRECAUTIONS |
Ofloxacin should be used with caution in patients having renal dysfunction, psychiatric disorders. Patients receiving ofloxacin therapy should avoid excess exposure to sunlight. |
| DRUG INTERACTIONS |
Concomitant use of ofloxacin and anti-coagulants may increase the effect of the latter. Concomitant use of ofloxacin and theophylline may increase theophylline steady state level although the clinical significance of this interaction is unclear. Concurrent use of ofloxacin and NSAID may lead to CNS excitation. Concurrent use of Ofloxacin and an Aluminium, Magnesium or Calcium containing antacid may result in decreased serum concentration of the antibiotic leading to loss of therapeutic efficacy. If the dose of Ofloxacin and antacid is separated by 2 hours the bioavailability of Ofloxacin is not decreased to a clinically significant extent. Administration of ferrous salt with Ofloxacin has been found to significantly reduce the absorption of Ofloxacin. Atleast 24 hours or more should be allowed between the administration of the last dose of Ofloxacin and live Typhoid vaccine. Fluroquinolones are capable of forming chelate complexes with metal ions including Calcium and Zinc resulting in reduced bioavailability of the Quinolone antibiotic. |
| DOSES AND ADMINISTRATION |
Adults- 200 -400 mg daily usually for 7-10 days depending on the severity of infection. Doses greater than 400 mg should be given in 2 divided doses.
- UTI- 200 - 800 mg daily
- LRTI - 400 - 800 mg daily
- Gonorrhoea - 400 mg as a single dose
- Prostatitis - 300 mg. twice a day for 6 weeks.
MDR TB: 300-800 mg daily in combination with other anti-tubercular drugs.
Children: Not recommended.
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| PACKING |
ENTOF 200: Strip of 10 tablets
ENTOF 400: Strip of 10 tablets |
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Horn 